STUDY OF THE ANTIOXIDANT SYSTEM AND LIPOPEROXIDATION PROCESS IN JUDOKAS ON THE BACKGROUND OF BASIC AND COMBINED THERAPY
DOI:
https://doi.org/10.69635/jiim.2025.2Keywords:
Arthritis, Antioxidant System, Peroxidation, Superoxide Dismutase, Catalase, Α-TocopherolAbstract
A study was conducted on the components of the antioxidant system: the content of superoxide dismutase (EC 1.15.1.1), catalase (EC 1.11.1.6) and α-tocopherol was studied in judokas of different ages and qualifications with rheumatoid arthritis. The studies were performed at baseline, and after the administration of antioxidant, combined therapy. During antioxidant therapy using ibuprofen (each tablet of which contains 100 mg of ascorbic acid), an increase in the activity of the studied enzymes and the concentration of α-tocopherol was noted. A positive effect of ibuprofen has been established, which is manifested, against the background of its use, by a more pronounced antioxidant effect, compared to standard, basic therapy. which helps to reduce the products of lipid peroxidation, as a result we avoid the total or partial destruction of cell membranes.
We can think that due to the specificity of the training and competition processes of judokas, the optimal intensification of peroxidic oxidation of lipids occurs, and the corresponding components of the antioxidant systems are not able to completely inhibit it. Although the antioxidant therapy performed by us delays the peroxidation processes, it cannot completely inhibit the action of their toxic metabolites. In our case, this is probably due to either the low concentration of the antioxidant used or the short course of treatment with the antioxidant during the antioxidant therapy.
We express an opinion: the activity of components of the antioxidant system in judokas can be increased not only by medical intervention, but also by taking physical rehabilitation and high-calorie, protein food products containing substances with antioxidant properties.
References
Anisimov V. N. Chronometer of life Archived February 2, 2017, at the Wayback Machine // Priroda. - 2007. - No. 7. P. 33-410.14302/issn.2471-2140.jaa-19-2997.
Arendt J. Melatonin: Characteristics, concerns , and prospects // J. Biol. Rhytms.-2005.- Vol.20, № 4. P.291-303.
Anisimov V.N. The role of pineal gland in the breast cancer development // Crit. Rev. Onkol. Hematoi.-2003—Vol.46, № 3. P.221-234.
Bradford M, arapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal.Biochem. 1976, 72, 248-254.
Bobrovsky A.V. Managing sports motivation of highly qualified wrestlers at the stage of direct preparation for competitions (using judo as an example): author's abstract. diss. … candidate of pedagogical sciences. Omsk, 2005
Deponte M. Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes //Biochim. Biophys. Acta. 2013. Vol. 830. P. 3217-3266.
Devasagayam T.P.A., Tilak J.C., Boloor K.K., Sane K.S., Ghaskadbi S.S., Lele R.D. Free radicals and antioxidants in human health: current status and future prospects // Japi. 2004: 52 (10): 794-804
Gerasimova, E.L. Study of antioxidant activity of fat-soluble objects by potentiometric method with mediator system / E.L. Gerasimova, A.V. Rogoznikova, H.Z. Braynina // Abstracts of reports of the VIII International conference. – M.: RUDN, 2010. – 558 p.
Goldring JPD. Measuring Protein Concentration with Absorbance, Lowry, Bradford Coomassie Blue, or the Smith Bicinchoninic Acid Assay Before Electrophoresis. Methods Mol Biol. 2019;1855:31-39. doi: 10.1007/978-1-4939- 8793-1_3. PMID: 30426404.
Halliwell B.H., Gutteridge J.M. Free Radicals in Biology and Medicine. Fourth Edition. Oxford: Oxford Univ. Press, 2007. 888 p.
Jomova K., Valko M. Advances in metal-induced oxidative stress and human diseases // Toxicology. 2011. Vol. 283. P. 65–87 .
Lankin, V. Z., Shadyro, O. I., Shumaev, K. B., Tikhaze, A. K., and Sladkova, A. A. (2019) Non-enzymatic methylglyoxal formation from glucose metabolites and generation of superoxide anion radical during methylglyoxal-dependent cross-links reaction, J. Antioxidant Activity, 2019.Vol.
Lobo V., Patil A., Phatak A., Chandra N. Free radicals, antioxidants and functional foods: Impact on human health // Pharmacognosy Reviews. 2010; 4 (8): 118–126. DOI: 10.4103/0973-7847.70902
Matasova L. B. Laboratory works and tasks in biochemistry. Voronezh: VSU. 2006
Medina M.E., Galano A., Alvarez-Idaboy J.R. Site reactivity in the free radicals induced damage to leucine residues: a theoretical study // Phys. Chem. Phys. 2015. Vol. 17. P. 4970–4976
Mehrdad R., Aghdaei S., Pouryaghoub G. Urinary 8-hydrtoxydeoxyguanosine as a biomarker of oxidative DNA damage in employees of subway system // Acta Med. Iran. 2015. Vol. 53. P. 287– 294
Putilina, F.E., Galkina O.V., Yeshchenko N.D. Free radical oxidation / edited by N.D. Yeshchenko. – St. Petersburg: Publishing house of St. Petersburg University, 2008. – 161 p.
Uzbekov M.G. Lipid peroxidation and antioxidant systems in mental illnesses. Communication I // Social and Clinical Psychiatry. 2015. Vol. 25, No. 4. P. 92–101.
Shumilin A.P. Motivation in the structure of the effectiveness of competitive activity of judoists: diss. ... candidate of ped. sciences. Krasnoyarsk, 2003
Theory and methodology of modern sports research: monograph / V.P. Guba, V.V. Marinich. - M.: Sport, 2016. - 233 p.
Published
Issue
Section
License
Copyright (c) 2025 Garuchava M. V., Khajidisi P. N., Revishvili A. V., Beriashvili K. M. (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
All articles are published as open access and are licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0). This means that authors retain the copyright to the content of their articles. Under the CC BY 4.0 license, the content can be copied, adapted, displayed, distributed, republished, or otherwise reused for any purpose, including commercial use, provided that proper attribution is given to the original authors.
How to Cite
